Silsiilay narrates the stories of three women. It's an upbeat and entertaining look at relationships.

Rehana (Tabu) is a housewife who must confront the fact that her husband Anwar (Kay Kay Menon) is being unfaithful to her. Preeti (Celina Jaitley) plays the third end of the tempestuous triangle.

Zia (Bhumika Chawla) is a fast rising Bollywood actress whose live-in relationship is about to break up with the man who groomed her for a film career, Neel (Rahul Bose). Divya Dutta features in a pivotal supporting role.

Anushka (Riya Sen) is a telephone receptionist who longs to discover tenderness in her relationship with a wealthy suitor Nikhil (Ashmit Patel). Meanwhile her office colleague, Tarun (Jimmy Shergill), loves her silently. The working girl must decide between the two in a romantic finale that has a twist in the tale. Natassha features in an impactful role.

The three stories are weaved into a composite picture, with the woman coming together in an act of solidarity.